Tuesday, July 17, 2012

Schistosomiasis: A disease among TRAVELERS [Parasitology]


By Sara Parvez

Schistosomiasis is a disease caused by penetration of parasitic worms in the skin. The parasite that penetrates the human skin is called cercaria which resides in a freshwater snail. Freshwater include pond, rivers, streams, or lakes. The infection cannot be acquired by contact with salt water of oceans and seas due to chlorination. A person can get infected by walking, swimming, or having any other contact with freshwater in disease endemic countries. Cercaria contaminates the water by swimming toward the human host and infecting it.  More than 200 million people are infected worldwide. Schistosomiasis is second only to malaria as the parasitic disease that cause most devastating. There are five types of Schistosomiasis distributed wouldwide. Out of five species three main ones infecting humans are S. haematobius, S. japonicum and S. mansoni which are found mainly in tropical and subtropical areas. Ever since the increase in tourism throughout Africa, sub-Saharan Africa, and South America there has been an increase in the number of schistosomiasis cases.

Complex Life cycle

1. Contact with the parasite in a freshwater.
2. Parasite enters the skin takes 3 days to reach blood capillaries.
3. Over the next 7 days the parasite migrates to the lungs, heart then the liver.
4. In liver they mature into adult worms and form male and female.
5. The average life span of the worm is 5 years, but can live up to 20 years.
6. The eggs release penetrates the bladder wall and goes in the urine. 
7. Eggs are eliminated in urine. In freshwater they can develop into mature blood flukes.
8. The eggs hatch and release miracidia which search for a snail host.
9. Between 4-6 weeks the infected snail release 3000 cercariae per day.
10. Cercariae penetrate human skin exposed in the water thus the life cycle begins again.

Areas where human schistosomiasis is found:

S. mansoni: Africa, South America and Caribbeans. An estimated 85% of the world’s cases of schistosomiasis are in Africa.
S. haematobium is distributed throughout Africa and sub-Saharan Africa including the great lakes. And areas of the Middle East
S. japonicum: Found in Indonesia and parts of China and Southeast Asia
S. mekongi: Found in Cambodia and Laos parts of Central and West Africa


Image displays the distribution of the cases of Schistosomiasis  due to Schistosoma haematobium, Schistosoma japonicum, and Schistosoma mekongi.


Image displays the distribution of the cases of Schistosoma mansoni and Schistosoma intercalatum.
 
Advice for Travelers

Travelers can avoid getting contact with the cercariae larvae by avoiding walking, swimming, or having any other contact with freshwater in disease endemic countries. Travelers should research on areas containing Schistosomasis epidemic before visiting them. If contact is unavoidable a person must take protective measures and undergo a checkup at a certified health center with knowledge in tropical medicine for recommendations. Always drink safe water by boiling water which can kill many bacteria and parasites. Take bath in hot water. Another way of avoiding contact with cercariae larvae in freshwater is by vigorously rubbing of the body with a towel. This brief method may or may not prevent the parasite form penetrating the skin, but it is effective most of the time. No vaccine is available. The drug of choice for all species of schistosomiasis is praziquantel.

References

Corachan M. Schistosomiasis and international travel. Clin Infect Dis. 2002 Aug 15;35(4):447–449.

Centers for Disease Control and Prevention. National Center for Health Statistics. Health Data Interactive. 9 July. 2012.

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